GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs10771431 | 1 | rs11611670 | chr12:9385535 | LOC642846 | chr12:9436253-9466684:+ | 0.17 | 7.01 | 4.13E-12 | Breast size |
| BRCA | cis | rs12303914 | 1 | rs11612335 | chr12:10474096 | KLRD1 | chr12:10457050-10469849:+ | 0.11 | 4.25 | 2.31E-5 | Thiazide-induced adverse metabolic effects in hypertensive patients |
| BRCA | cis | rs11622475 | 1 | rs11622475 | chr14:104509076 | TDRD9 | chr14:104394817-104519002:+ | 0.35 | 7.78 | 1.67E-14 | Bipolar disorder |
| BRCA | cis | rs116988415 | 1 | rs11622962 | chr14:65299145 | CHURC1 | chr14:65381140-65411309:+ | 0.33 | 5.08 | 4.51E-7 | Daytime sleep phenotypes |
| BRCA | cis | rs910316 | 1 | rs11623413 | chr14:75588824 | EIF2B2 | chr14:75469612-75476292:+ | -0.16 | -4.44 | 9.9E-6 | Height |
| BRCA | cis | rs910316 | 1 | rs11623413 | chr14:75588824 | MLH3 | chr14:75480467-75518235:- | -0.18 | -5.76 | 1.13E-8 | Height |
| BRCA | cis | rs11622475 | 1 | rs11625697 | chr14:104464800 | TDRD9 | chr14:104394817-104519002:+ | 0.42 | 10.69 | 2.1E-25 | Bipolar disorder |
| BRCA | cis | rs997295 | 1 | rs11630417 | chr15:68012609 | IQCH | chr15:67547188-67794139:+ | 0.14 | 5.08 | 4.44E-7 | Motion sickness |
| BRCA | cis | rs997295 | 1 | rs11630417 | chr15:68012609 | LBXCOR1 | chr15:68117941-68126174:+ | 0.12 | 3.7 | 0.000224 | Motion sickness |
| BRCA | cis | rs783540 | 1 | rs11631963 | chr15:83318202 | FAM154B | chr15:82555152-82577265:+ | 0.13 | 3.91 | 9.89E-5 | Schizophrenia |
| BRCA | cis | rs783540 | 1 | rs11631963 | chr15:83318202 | GOLGA6L9 | chr15:82711895-82731584:+;chr15 | 0.1 | 3.63 | 0.000302 | Schizophrenia |
| BRCA | cis | rs8030379 | 1 | rs11633301 | chr15:84585038 | GOLGA6L5 | chr15:85047738-85060078:- | 0.14 | 4.7 | 2.87E-6 | Waist circumference adjusted for body mass index;Waist circumference |
| BRCA | cis | rs11633958 | 1 | rs11633958 | chr15:78862064 | AGPHD1 | chr15:78799906-78829714:+ | -0.16 | -3.47 | 0.000545 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio in COPD;Post bronchodilator FEV1/FVC ratio |
| BRCA | cis | rs11633958 | 1 | rs11633958 | chr15:78862064 | CHRNA5 | chr15:78857906-78886458:+ | -0.21 | -5.95 | 3.74E-9 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio in COPD;Post bronchodilator FEV1/FVC ratio |
| BRCA | cis | rs997295 | 1 | rs11637027 | chr15:67937755 | IQCH | chr15:67547188-67794139:+ | 0.14 | 4.85 | 1.39E-6 | Motion sickness |